GB/T 15670.19-2017 English PDF

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GB/T 15670.19-2017: Toxicological test methods for pesticides registration -- Part 19: In vitro mammalian cells chromosome aberration test
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Basic data

Standard ID: GB/T 15670.19-2017 (GB/T15670.19-2017)
Description (Translated English): Toxicological test methods for pesticides registration -- Part 19: In vitro mammalian cells chromosome aberration test
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: B17
Classification of International Standard: 65.100
Word Count Estimation: 6,647
Date of Issue: 2017-07-12
Date of Implementation: 2018-02-01
Regulation (derived from): s Republic of China
Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China

GB/T 15670.19-2017: Toxicological test methods for pesticides registration -- Part 19: In vitro mammalian cells chromosome aberration test

---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Toxicological test methods for pesticides registration - Part 19. In vitro mammalian cells chromosome aberration test ICS 65.100 B17 National Standards of People's Republic of China Pesticide registration toxicology test method Part 19. In vitro mammalian cell chromosomes Distortion test Part 19. Invitromammaliancelschromosomeaberrationtest 2017-07-12 released 2018-02-01 Implementation General Administration of Quality Supervision, Inspection and Quarantine of the People 's Republic of China China National Standardization Management Committee released

Foreword

GB/T 15670 "Pesticide registration toxicology test method" is divided into the following parts. - Part 1. General; - Part 2. Acute oral toxicity test; - Part 3. Sequential method of acute oral toxicity test; - Part 4. Acute oral toxicity test probability unit method; - Part 5. Acute percutaneous toxicity test; - Part 6. Acute inhalation toxicity test; - Part 7. Skin irritation/corrosivity test; - Part 8. Acute eye irritation/corrosivity test; - Part 9. Skin allergy (sensitization) test; - Part 10. Short-term repeated oral exposure (28 days) toxicity test; - Part 11. Short term repeated percutaneous exposure (28 days) toxicity test; - Part 12. Short-term repeated inhalation exposure (28 days) toxicity test; - Part 13. Subchronic toxicity test; - Part 14. Bacterial response mutations; - Part 15. Micronucleus test of mammalian bone marrow polychromatic erythrocytes; - Part 16. Chromosome aberration test of mammalian bone marrow cells in vivo; - Part 17. Chromosome aberration of spermatogonia/spermatocytes in mammals; - Part 18. Sexual lethal test of rodents; - Part 19. In vitro mammalian cell chromosome aberration test; - Part 20. In vitro mammalian cell gene mutation test; Part 21. Systemic DNA synthesis (UDS) test for mammalian hepatocytes in vivo; - Part 22. DNA damage and repair/programmed DNA synthesis in mammalian cells in vitro; - Part 23. Teratogenic tests; - Part 24. Two generations of reproductive toxicity tests; - Part 25. Acute delayed neurotoxicity test; - Part 26. Chronic toxicity test; - Part 27. Cancer test; - Part 28. Chronic toxicity and carcinogenesis trials; - Part 29. Metabolic and toxic kinetic tests. This part is part 19 of GB/T 15670. This part is drafted in accordance with the rules given in GB/T 1.1-2009. This part of the People's Republic of China Ministry of Agriculture made and centralized. This part of the drafting unit. Ministry of Agriculture Pesticide Testing Institute. This part of the main drafters. Zhang Hongwei, Zhang Liying, Tao Chuanjiang. Pesticide registration toxicology test method Part 19. In vitro mammalian cell chromosomes Distortion test

1 Scope

This part of GB/T 15670 specifies the basic principles, methods and requirements for chromosomal aberrations in mammalian cells in vitro. This section applies to chromosomal aberration tests of in vitro mammalian cells for pesticide registration.

2 normative reference documents

The following documents are indispensable for the application of this document. For dated references, only the dated edition applies to this article Pieces. For undated references, the latest edition (including all modifications) applies to this document. GB/T 15670.14-2017 Pesticide registration - Toxicology test method - Part 14. Bacteria recovery mutation test

3 terms and definitions

The following terms and definitions apply to this document. 3.1 Structural distortion In the mid-phase phase of cell division, the chromosome structure detected by microscopy changes, manifested as missing, fragmented, interchange and so on. Structural distortion Can be divided into chromosome aberration (chromosome-typeaberration) and chromosome haplotype (chromatid-typeaberration) Two categories. 3.2 Chromosome haplotype Chromosome structure damage, manifested as staining of the monomer or fracture of the monomer. 3.3 Chromosome - type aberration The chromosomal structure is characterized by changes in fracture or rupture recombination at the same site of the two dyed monomers. 3.4 Mitotic index mitoticindex The ratio of the number of mesophase cells to the total number of cells observed is an indicator of the degree of cell proliferation. 3.5 Polyploid polyploidy The number of chromosomes in mammalian cells is normal diploid, and the number of chromosomes is multiplied by the action of chemical mutagens, Body, tetraploid and so on.

4 Purpose of the test

This test examines whether the test substance causes chromosomal aberrations in cultured mammalian cells to assess the likelihood of mutagenicity in the subject. ......

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