SN/T 2291: Evolution and historical versions
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| SN/T 2291-2024 | English | RFQ |
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(Determination of dextromethorphan hydrobromide in imported and exported cosmetics - Liquid chromatography)
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SN/T 2291-2024
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| SN/T 2291-2009 | English | 479 |
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Determination of dextromethorphan hydromide in cosmetics for import. Liquid chromatography method
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SN/T 2291-2009
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PDF similar to SN/T 2291-2024
Basic data | Standard ID | SN/T 2291-2024 (SN/T2291-2024) | | Description (Translated English) | (Determination of dextromethorphan hydrobromide in imported and exported cosmetics - Liquid chromatography) | | Sector / Industry | Commodity Inspection Standard (Recommended) | | Classification of Chinese Standard | Y42 | | Classification of International Standard | 71.100.70 | | Date of Issue | 2024-12-16 | | Date of Implementation | 2025-06-01 | | Issuing agency(ies) | General Administration of Customs | SN/T 2291-2009: Determination of dextromethorphan hydromide in cosmetics for import. Liquid chromatography method
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Determination of dextromethorphan hydromide in cosmetics for import.Liquid chromatography method
Exit inspection and quarantine industry standard book People's Republic of China
Determination of dextromethorphan hydrobromide and export cosmetics
Liquid chromatography
Posted 2009-02-20
2009-09-01 implementation
People's Republic of China
The State Administration of Quality Supervision, Inspection and Quarantine released
Foreword
Appendix A of this standard is an informative annex.
This standard is proposed and managed by the National Certification and Accreditation Administration Committee.
This standard was drafted. Tianjin People's Republic of China Exit Inspection and Quarantine.
The main drafters of this standard. Wu Yanhui, Xu Hong, Lin Anqing, Xiaoya Bing, Gu Long, Zhang Man, He Jia, Zhang Jun.
This standard is the first release of the entry-exit inspection and quarantine industry standards.
Determination of dextromethorphan hydrobromide and export cosmetics
Liquid chromatography
1 Scope
This standard specifies the method of liquid chromatography and export cosmetics dextromethorphan hydrobromide.
This standard applies to cosmetics dextromethorphan hydrobromide detection.
Principle 2
Extracted with methanol in a sample of dextromethorphan hydrobromide, extract by centrifugal filtration, liquid chromatography - fluorescence detector, external standard method
Quantified.
3 Reagents and materials
3.1 acetonitrile. chromatography.
3.2 Methanol. chromatographically pure.
3.3 triethylamine. chromatography.
3.4 glacial acetic acid. Chromatographic pure.
3.5 3% acetic acid solution. Measure 30mL of glacial acetic acid to volume with water to 1L, adjusted with triethylamine to pH = 4.3.
Dextromethorphan hydrobromide 3.6 Standard substance. purity ≥99%.
3.7 dextromethorphan hydrobromide standard stock solution. accurately weighed amount of dextromethorphan hydrobromide standard substance (accurate to 0.1mg), methanol
Preparation of a concentration of 1000μg/mL of the standard stock solution.
3.8 standard solution. According to the standard sensitivity and linear range of the instrument, diluted to the appropriate concentration of standard working solution with methanol.
3.9 0.22μm organic phase filters.
3.10 scale stoppered centrifuge tube. 15mL.
4 Instrument
4.1 High performance liquid chromatograph. equipped with fluorescence detector.
4.2 Analysis of balance. a sense of the amount of 0.1mg.
4.3 ultrasonic bath.
4.4 refrigerated centrifuge (speed is greater than 3500r/min).
4.5 freezer (-18 ℃).
5 measuring step
5.1 Sample Processing
Weigh a sample of about 1.0g (accurate to 0.01g), in 15mL graduated centrifuge tube with a stopper, methanol was added 8mL, shake vigorously the matrix
After uniformly dispersed, the solution volume to 10mL, ultrasound in an ultrasonic bath 20min, mix in the refrigerator freezer (-18 ℃ or lower temperature
After degrees) placed 10min, centrifuged at 5min at 3500r/min, the sample to room temperature, the supernatant through 0.22μm membrane organic
Filtered and the filtrate for liquid chromatography.
5.2 Determination
5.2.1 HPLC conditions
5.2.1.1 fluorescence detector. excitation wavelength of 280nm, emission wavelength 310nm.
5.2.1.2 Column. Phenomenex5μm C8,250mm × 4.6mm, 5μm.
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