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GB/T 40145-2021: Determination of 11 glucocorticoids including desonide in cosmetics - Liquid chromatography-tandem mass spectrometry
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| Standard ID | Contents [version] | USD | STEP2 | [PDF] delivered in | Standard Title (Description) | Status | PDF |
| GB/T 40145-2021 | English | 259 |
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Determination of 11 glucocorticoids including desonide in cosmetics - Liquid chromatography-tandem mass spectrometry
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GB/T 40145-2021
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Basic data | Standard ID | GB/T 40145-2021 (GB/T40145-2021) | | Description (Translated English) | Determination of 11 glucocorticoids including desonide in cosmetics - Liquid chromatography-tandem mass spectrometry | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | Y42 | | Word Count Estimation | 14,147 | | Issuing agency(ies) | State Administration for Market Regulation, China National Standardization Administration | GB/T 40145-2021: Determination of 11 glucocorticoids including desonide in cosmetics - Liquid chromatography-tandem mass spectrometry
---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
Determination of 11 glucocorticoids including desonide in cosmetics-Liquid chromatography-tandem mass spectrometry
ICS 71.100.70
CCSY42
National Standards of People's Republic of China
Eleven glucocorticoids such as dessononide in cosmetics
Determination of liquid chromatography/tandem mass spectrometry
Released on 2021-05-21
2021-12-01 implementation
State Administration of Market Supervision and Administration
Issued by the National Standardization Management Committee
Foreword
This document is in accordance with the provisions of GB/T 1.1-2020 "Guidelines for Standardization Work Part 1.Structure and Drafting Rules of Standardization Documents"
Drafting.
This document was proposed and managed by the National Standardization Technical Committee on Inspection Methods for Key Products of Quality Supervision (SAC/TC374).
Drafting organizations of this document. Guangzhou Institute of Quality Supervision and Inspection, Shenzhen Institute of Drug Inspection, CCIC Warner (Beijing) Quality Technology Center
Heart Co., Ltd., Warner Pass (Beijing) Certification Co., Ltd., Yujiahui Co., Ltd., Oushiman Biological Co., Ltd., Guangzhou Branch
Neng Cosmetics Scientific Research Co., Ltd., Infinitus (China) Co., Ltd., Guangdong Lichuang Testing Technology Service Co., Ltd., Guangdong Marumi Biotechnology
Co., Ltd., Guangzhou Jintong Biotechnology Co., Ltd., China Inspection Union (Beijing) Quality Inspection Technology Research Institute Co., Ltd.
The main drafters of this document. Tan Jianhua, Xiong Xiaoting, Zhang Gaofei, Wang Jicai, Chen Yiguang, Xia Zemin, Liang Wenyao, Qiu Yingheng, Wang Yaru,
Li Huiyong, Xi Shaofeng, Wu Yuluan, Meng Jie, Li Chuanmao, Dai Yuefeng, Wang Jing, Sun Hongmei, Kong Lingchao, Lin Shengjie, Luo Zhihuan, Sun Yunqi, Zhang Qing,
Li Huazhen and Chen Dongyang.
Introduction
The tested substances in this document are prohibited substances stipulated in my country's "Cosmetics Safety Technical Specifications".
Prohibited substances refer to substances that cannot be added to cosmetics as raw materials or components in cosmetics production. "Cosmetics Safety Technical Specifications" regulations
Determination. If it is technically unavoidable to bring prohibited substances into cosmetics as impurities, a safety risk assessment should be carried out to ensure that they are normal, reasonable and available.
It shall not cause harm to human health under the foreseeable use conditions.
At present, my country has not yet stipulated the limit value of these substances. This document only provides detection methods for the determination of these substances in cosmetics.
Eleven glucocorticoids such as dessononide in cosmetics
Determination of liquid chromatography/tandem mass spectrometry
1 Scope
This document specifies the determination of dessononide, 16α-hydroxyprednisolone, and 16α-hydroxyprednisone in cosmetics by liquid chromatography/tandem mass spectrometry
Dragon Acetate, Diflurazone, Fluocinolone, Dexamethasone, Paramethasone Acetate, Desonide-21-Acetate, Methylprednisolone Acetate Propionate
Principles, reagents and materials, equipment and measurement procedures of eleven glucocorticoids, halbetasol propionate and betamethasone butyrate propionate
Steps, calculation of results, recovery rate and precision, etc.
This document is applicable to liquids, lotions, creams (except wax-based), and essential oil cosmetics.
2 Normative references
The contents of the following documents constitute the indispensable clauses of this document through normative references in the text. Among them, dated quotations
Only the version corresponding to that date is applicable to this document; for undated reference documents, the latest version (including all amendments) is applicable to
This document.
GB/T 6682 Analytical laboratory water specifications and test methods
GB/T 24800.2-2009 Determination of 41 glucocorticoids in cosmetics Liquid chromatography/tandem mass spectrometry and thin layer
Analysis
3 Terms and definitions
The terms and definitions defined in GB/T 24800.2-2009 apply to this document.
4 Principle
Essential oil cosmetics are dispersed with n-hexane, 70% acetonitrile aqueous solution is extracted, water, emulsion, cream cosmetics are extracted with acetonitrile, and the liquid
Chromatography/tandem mass spectrometer determination, external standard method quantification.
5 Reagents and materials
Unless otherwise stated, only chromatographically pure reagents are used.
5.1 Water, GB/T 6682, level one.
5.2 Methanol.
5.3 Acetonitrile.
5.4 Formic acid.
5.5 n-hexane. analytically pure.
5.6 50% acetonitrile aqueous solution. accurately measure 500mL acetonitrile (5.3) and 500mL water, mix well and set aside.
5.7 70% acetonitrile aqueous solution. accurately measure 700mL of acetonitrile (5.3) and 300mL of water, mix well and set aside.
5.8 0.1% formic acid aqueous solution. accurately pipette 1mL formic acid (5.4) to a 1000mL volumetric flask, and dilute to the mark with water.
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