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GB/T 39261-2020: Nanotechnologies. Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment
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Nanotechnologies. Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment
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GB/T 39261-2020
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Basic data | Standard ID | GB/T 39261-2020 (GB/T39261-2020) | | Description (Translated English) | Nanotechnologies. Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment | | Sector / Industry | National Standard (Recommended) | | Classification of Chinese Standard | A40 | | Classification of International Standard | 71.040.50 | | Word Count Estimation | 33,368 | | Date of Issue | 2020-11-19 | | Date of Implementation | 2021-06-01 | | Adopted Standard | ISO/TR 13014-2012, IDT | | Regulation (derived from) | National Standard Announcement No. 26 of 2020 | | Issuing agency(ies) | State Administration for Market Regulation, China National Standardization Administration | | Summary | This standard specifies the guidance for the characterization of physical and chemical properties of man-made nano-objects and aggregates and aggregates (NOAA) larger than 100 nm. The purpose is to provide assistance in evaluating and clarifying the impact of physical and chemical properties on toxicological effects, and can also be used to distinguish between test items The material is similar to it. This standard specifies description, explanation, correlation, to-be-measured and test method examples for each physical and chemical property. This standard has reference value for researchers who are committed to studying the potential toxicological effects of NOAA (such as toxicologists, ecotoxicologists, managers, health and safety experts). | GB/T 39261-2020: Nanotechnologies. Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment
---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.
(Nanotechnology Guidelines for the characterization of physical and chemical properties of nanomaterials before toxicological evaluation)
ICS 71.040.50
A40
National Standards of People's Republic of China
nanotechnology
Guidelines for characterization of physical and chemical properties of nanomaterials before toxicological evaluation
2020-11-19 released
2021-06-01 implementation
State Administration for Market Regulation
Issued by the National Standardization Management Committee
Table of contents
Preface Ⅲ
Introduction Ⅳ
1 Scope 1
2 Terms and definitions 1
3 Abbreviations 5
4 Importance of physicochemical characterization before toxicological assessment 5
5 Characterization parameters of physical and chemical properties of nano-objects before toxicological assessment 9
6 Measurement results and uncertainty 16
7 Report 17
Appendix A (informative appendix) illustrates the application of physical and chemical characterization in toxicological testing 19
Appendix B (Informative Appendix) Examples of Measurement Methods and Standards 20
Reference 23
Foreword
This standard was drafted in accordance with the rules given in GB/T 1.1-2009.
This standard uses the translation method equivalent to ISO /T R13014.2012 "Nanotechnology and Nanomaterials Physical and Chemical Properties before Toxicology Evaluation"
Enlistment Guide.
This standard has made the following editorial changes.
---Reorder the references.
This standard was proposed by the Chinese Academy of Sciences.
This standard is under the jurisdiction of the National Nanotechnology Standardization Technical Committee (SAC/TC279).
Drafting organization of this standard. National Nano Science Center.
The main drafters of this standard. Bai Ru, Chen Chunying.
Introduction
In recent years, with the widespread application of nanomaterials in consumer goods and other products, people have increasingly paid attention to exposure to nanomaterials (especially
It is the health and environmental problems that may be caused by nano-objects and their aggregates and aggregates (NOAA)]. Although there has been a lot of information about NOAA
However, most of these studies did not provide detailed physical and chemical characterization data, or did not evaluate and compare the test results obtained.
fruit. Given that different NOAAs have similar compositions, specific physical and chemical characterization is the key to determining the material under study, and is conducive to further
Step to understand the toxicity of nanomaterials.
This guide provides guidance for the physical and chemical characterization of commercial man-made nano-objects before toxicity assessment (including population and ecological assessment). The purpose is to cooperate
To help scientists in other fields understand, plan, identify and confirm the physical and chemical properties of these materials before conducting toxicological research.
The premise of academic evaluation is consistent with other ISO standards. For example, ISO 10993-18 provides chemical tables for materials used in medical equipment.
According to ISO 14971, toxicological risk analysis needs to consider the chemical properties of materials.
Characterization of physical and chemical properties can provide important information for a better understanding of the relationship between toxicological test results and physical and chemical properties. This guide
The following valuable physical and chemical characterization information is provided to facilitate subsequent toxicological evaluation.
---How does the physical and chemical characterization fit in with NOAA's toxicology testing process;
---Physical and chemical characterization is the key to toxicology testing;
---What parameters are included in the physical and chemical characterization.
nanotechnology
Guidelines for characterization of physical and chemical properties of nanomaterials before toxicological evaluation
1 Scope
This standard provides guidance on the characterization of physical and chemical properties of man-made nano-objects and aggregates and aggregates (NOAA) larger than 100 nm.
The purpose is to provide assistance in evaluating and clarifying the influence of physical and chemical properties on toxicological effects, and it can also be used to distinguish the material to be tested from its similar materials.
material. This standard provides descriptions, instructions, correlations, examples of methods to be measured and test methods for each physical and chemical property.
This standard is intended for researchers who are committed to studying the potential toxicological effects of NOAA (such as toxicologists, ecotoxicologists, management personnel,
Health and safety experts) have reference value.
2 Terms and definitions
ISO /T S27687, ISO /T S80004-1, ISO /T S80004-3, ISO /IEC Guide99 and the following terms and definitions apply to this document.
2.1
Aggregates
The external surface area of new particles composed of strongly bound or fused particles may be significantly smaller than the sum of the surface areas of individual particles.
Note 1.The forces supporting the aggregates are strong forces, such as covalent bonds or derived from sintering or complex physical entanglement.
Note 2.Aggregates are also called secondary particles, while source particles are called primary particles.
[ISO /T S27687.2008, definition 3.3]
2.2
Aggregates
The aggregates, aggregates, or mixtures of weakly bound particles have an external surface area similar to the sum of the surface area of individual particles.
Note 1.The forces supporting the agglomerates are weak forces, such as van der Waals forces or simple physical entanglements.
Note 2.Agglomerates are also called secondary particles, while source particles are called primary particles.
[ISO /T S27687.2008, definition 3.2]
2.3
Carbon nanotube
Nanotubes made of carbon atoms.
Note. It is usually composed of crimped carbon monolayers, including single-wall carbon nanotubes and multi-wall carbon nanotubes.
[ISO /T S80004-3.2010, definition 4.3]
2.4
colloid
A multi-phase substance composed of nanoparticles (1nm to 100nm) uniformly suspended in a liquid (dispersion medium) by the action of electric charges, which
These particles exhibit Brownian motion and electrophoresis.
Note 1.It has colloidal properties.
Note 2.Rewrite ISO 1942-2.
2.5
composition
The properties of nanomaterials are determined by the characteristics and composition of each specific component.
Note. Rewrite ISO 6141.
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