GB/T 21605-2025 English PDF

Standard ID	USD	BUY PDF	Lead-Days	Standard Title (Description)	Status
GB/T 21605-2025	359	Add to Cart	4 days	Chemicals - Test method of acute inhalation toxicity	Valid
GB/T 21605-2008	489	Add to Cart	4 days	Chemicals -- Test method of acute inhalation toxicity	Valid

Basic data

Standard ID: GB/T 21605-2025 (GB/T21605-2025)
Description (Translated English): Chemicals - Test method of acute inhalation toxicity
Sector / Industry: National Standard (Recommended)
Classification of Chinese Standard: A80
Classification of International Standard: 13.300
Word Count Estimation: 18,181
Date of Issue: 2025-08-29
Date of Implementation: 2025-12-01
Older Standard (superseded by this standard): GB/T 21605-2008
Issuing agency(ies): State Administration for Market Regulation; Standardization Administration of China

GB/T 21605-2025: Chemicals - Test method of acute inhalation toxicity

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ICS 13.300 CCSA80 National Standards of the People's Republic of China Replaces GB/T 21605-2008 Acute inhalation toxicity test method for chemicals Published on 2025-08-29 Implemented on December 1, 2025 State Administration for Market Regulation The State Administration for Standardization issued a statement.

Foreword

This document complies with the provisions of GB/T 1.1-2020 "Standardization Work Guidelines Part 1.Structure and Drafting Rules of Standardization Documents". Drafting. This document supersedes GB/T 21605-2008 "Test Methods for Acute Inhalation Toxicity of Chemicals" and is consistent with GB/T 21605-2008. Aside from structural adjustments and editorial changes, the main technical changes are as follows. ---The chapter on "Scope" has been revised (see Chapter 1, Chapter 1 of the.2008 edition); ---Terminology and definitions have been revised (see Chapter 3, Chapter 2 of the.2008 edition); ---Added evaluation of whether the test substance can be absorbed through the respiratory tract (see Chapter 4); ---Added the principles of pre-experiment data collection and analysis, and the traditional LC50 method and concentration-time method (see Chapter 5); ---Added exposure condition monitoring (see 6.6), removed the static exposure method (see 5.3.1 in the.2008 version), and changed the dynamic exposure method. Compared to the traditional LC50 method and concentration-time method (see 6.7, 5.3.2 in the.2008 edition), clinical observation, weight monitoring, and pathological studies have been added. Check (see 6.8); ---The section on "Experimental Data and Reporting" has been revised (see Chapter 7, 5.5, Chapter 6, and Chapter 7 of the.2008 edition); ---A "concentration-time method" has been added (see Appendix A). Please note that some content in this document may involve patents. The issuing organization of this document assumes no responsibility for identifying patents. This document was proposed and is under the jurisdiction of the National Technical Committee on Standardization of Hazardous Chemicals Management (SAC/TC251). This document was drafted by. Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention; Guangdong Provincial Institute of Occupational Disease Prevention and Control; and Fujian Ningjia. Jun Testing Technology Service Co., Ltd. The main drafters of this document are. Liu Lili, Zeng Lihai, Zhang Yi, Xie Zhiwei, Zheng Jiewei, Li Bin, Chen Xiao, Xiao Jingwei, Yu Tao, and Zhang Huaxin. The release history of this document and the document it replaces is as follows. ---First published in.2008 as GB/T 21605-2008; ---This is the first revision. Acute inhalation toxicity test method for chemicals 1.Scope This document describes the methods for testing the acute inhalation toxicity of chemicals. This document applies to acute inhalation toxicity testing of chemicals.

2 Normative references

The contents of the following documents, through normative references within the text, constitute essential provisions of this document. Dated citations are not included. For references to documents, only the version corresponding to that date applies to this document; for undated references, the latest version (including all amendments) applies. This document. GB 14925 Laboratory Animal Environment and Facilities 3.Terms and Definitions The following definitions and terms apply to this document. 3.1 Laboratory animals inhale a certain concentration of the test substance (gas, vapor, aerosol) continuously within a short period of time (24 hours or less). Health damage effects (or particulate matter). 3.2 Inhaled dose of inhaleddose The amount of test substance inhaled per unit body weight of laboratory animal. 3.3 The statistical significance of a toxicant that causes half the deaths in a group of experimental animals after a single continuous inhalation of the test substance within a specified time. concentration. Note. The test substance is expressed as the mass (mg/m3 or mg/L) or volume fraction (e.g., 10⁻⁶/10⁻⁹) of a unit volume of air. 3.4 In an aerosol sample composed of particles of varying aerodynamic diameters, particles smaller than or equal to a certain aerodynamic diameter... The aerodynamic diameter of aerosol particles when they account for 50% of the total mass or weight of the aerosol sample. 3.5 A dimensionless number used to describe the range of aerosol particle sizes. Note. The smaller the geometric standard deviation, the higher the proportion of particles of similar size, meaning better uniformity and lower dispersion of aerosol particles. A smaller geometric standard deviation... Aerosol samples with a value of 2 or greater are called single-phase dispersed aerosols. 3.6 Dose-response relationship The relationship between dose and the incidence of specific effects. ......

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