GB 22612-2008 English PDFUS$319.00 · In stock
Delivery: <= 3 days. True-PDF full-copy in English will be manually translated and delivered via email. GB 22612-2008: [GB/T 22612-2008] Cartap hydrochloride technical Status: Valid
Basic dataStandard ID: GB 22612-2008 (GB22612-2008)Description (Translated English): [GB/T 22612-2008] Cartap hydrochloride technical Sector / Industry: National Standard Classification of Chinese Standard: G25 Classification of International Standard: 65.100.10 Word Count Estimation: 12,183 Date of Issue: 2008-12-17 Date of Implementation: 2009-06-01 Quoted Standard: GB/T 1600; GB/T 1601; GB/T 1604; GB/T 1605-2001; GB 3796 Regulation (derived from): Announcement of Newly Approved National Standards No. 21 of 2008 (No. 134 overall) Issuing agency(ies): General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, Standardization Administration of the People's Republic of China Summary: This Chinese standard specifies the requirements cartap original drug, test methods and marking, labeling, packaging, storage and transportation. This standard applies to Cartap impurities generated in the production and composition of Cartap original drug. GB 22612-2008: [GB/T 22612-2008] Cartap hydrochloride technical---This is a DRAFT version for illustration, not a final translation. Full copy of true-PDF in English version (including equations, symbols, images, flow-chart, tables, and figures etc.) will be manually/carefully translated upon your order.Cartap hydrochloride technical ICS 65.100.10 G25 National Standards of People's Republic of China CARTAP original drug Posted 2008-12-17 2009-06-01 implementation Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China Standardization Administration of China released ForewordThe standard Chapter 3, Chapter 5 is mandatory, the rest are recommended. The standard proposed by China Petroleum and Chemical Industry Association. This standard by the National Standardization Technical Committee on Pesticides (SAC/TC133) centralized. This standard is drafted by. Shenyang Chemical Research Institute. Participated in the drafting of this standard. Jiang Su Tianrong Group Co., Ltd., Qingdao Hailier Pharmaceutical Company Limited. The main drafters of this standard. Meibao Gui, Xing Hong, Wang Qiang, Wen Shao. CARTAP original drug Other name, structural formula and basic physicochemical parameters of the active ingredient CARTAP product as follows. Generic Name. CARTAP ISO common name. Cartaphydrochloride Chemical Name. 1,3-bis (carbamoylmethyl S) -2-dimethylamino-propane hydrochloride Structure. CH CH 2SC H2 N N (CH3) 2 · HCl CH 2SC H2 N Empirical formula. C7H16ClN3O2S2 Molecular Weight. 273.8 (according to 2007 international relative atomic mass) Biological activity. Insecticidal Melting point. 179 ℃ ~ 181 ℃ (decomposition) Vapor pressure (25 ℃). small Solubility (25 ℃). water for about 200g/L, slightly soluble in methanol, ethanol, insoluble in acetone, ether, ethyl acetate, chloroform, benzene, n Hexane and other organic solvents Stability. stable under acidic conditions, hydrolysis in neutral and alkaline media. Hygroscopic, non-corrosive1 ScopeThis standard specifies the CARTAP original drug requirements, test methods and marking, labeling, packaging, storage and transportation. This standard applies to the CARTAP impurity generated in the production and composition CARTAP original drug.2 Normative referencesThe following documents contain provisions which, through reference in this standard and become the standard terms. For dated references, subsequent Amendments (not including errata content) or revisions do not apply to this standard, however, encourage the parties to the agreement are based on research Whether the latest versions of these documents. For undated reference documents, the latest versions apply to this standard. GB/T 1600 Determination of Water Pesticides Determination of GB/T 1601 Pesticides pH value GB/T 1604 Goods pesticide regulations for acceptance GB/T 1605-2001 Sampling Method commercial pesticides GB 3796 pesticide packaging General3 Requirements3.1 Appearance White powder or white crystals. 3.2 Technical Specifications CARTAP original drug should be consistent with the requirements in Table 1. Table 1 CARTAP original drug control project indicators Item Index CARTAP mass fraction /% ≥ 97.0 Moisture content /% ≤ 1.0 Score a /% Water insoluble mass ≤ 0.2 pH range 3.0 to 6.0 When a normal production, the quality of water insoluble fraction was measured at least once every three months. Test Method 4 4.1 Sampling According to GB/T 1605-2001 "on the original drug product sampling" approach. Determined by sampling a random number table method packages, the final sample size Not less than 100g. 4.2 Identification Test You can choose one of the following methods. When not identify one way, then use another method should be determined. Infrared spectroscopy --- CARTAP sample and standard samples in the infrared 4000cm-1 ~ 400cm-1 absorption spectrum should be no significant difference. CARTAP standard infrared spectrum is shown in Figure 1. Figure 1 CARTAP standard infrared spectrum HPLC --- The identification test can be carried out simultaneously with the determination of the mass fraction of CARTAP. In the same chromatographic operating conditions , The sample solution to a chromatographic retention time and CARTAP CARTAP standard solution peak retention time, the relative difference should 1.5% or less. Determination of the mass fraction of 4.3 CARTAP 4.3.1 Method summary Phosphoric acid aqueous sample was dissolved in heptane solution of sodium + acetonitrile as mobile phase, to use as filler Capcel-PakC18 stainless steel Column and UV detector (225nm), the sample of CARTAP reverse phase high performance liquid chromatography, external standard. 4.3.2 Reagents and solutions Acetonitrile. HPLC grade; Water. The new secondary steam distilled water; Phosphoric acid; Phosphoric acid. water with phosphoric acid adjusted to pH 2.5; Geng sodium; Triethylamine; Heptane sulfonate solution. Weigh 3.64g of sodium heptanoate in 1L wide-mouth bottle, add distilled water 900mL secondary shaking to dissolve, Phosphoric acid was added 16mL; then triethylamine adjusted to pH 2.0; CARTAP standard. a known mass fraction ≥99.0%. 4.3.3 Instruments High performance liquid chromatography. a variable wavelength UV detector; Chromatographic data processor or chromatography workstation; Column.200mm × 4.6mm (. I.d) stainless steel column, built Capcel-PakC18,5μm filler (or with equivalent effect color The column); Filter. filter pore size of about 0.45μm; Micro injector. 50μL; Quantitative sample line. 10μL; Ultrasonic cleaner. 4.3.4 HPLC operating conditions Mobile phase. ψ (heptane solution of sodium. acetonitrile) = 90.10, with 0.45μm filter membrane, ultrasound 10min spare; Flow rate. 1.0mL/min; Column temperature. room temperature (temperature change should not exceed 2 ℃); Detection wavelength. 225nm; Injection volume. 10μL; Retention time. 7.4min. It said operating parameters are typical, according to the characteristics of different instruments, given operating parameters adjusted as appropriate, in order to obtain the best results. Typical CARTAP original drug HPLC is shown in Figure 2. 1 --- CARTAP. HPLC Figure 2 CARTAP original drug 4.3.5 measuring step 4.3.5.1 Preparation of standard solution Weigh 0.05g (accurate to 0.0002g) CARTAP standard, a 50mL volumetric flask, dissolved in aqueous phosphoric acid and diluted to the mark Degree, shake. 4.3.5.2 Preparation of sample solution Weigh containing CARTAP 0.05g (accurate to 0.0002g) sample, placed in 50mL volumetric flask, and diluted with aqueous phosphoric acid To the mark. 4.3.5.3 Determination Under these operating conditions, after the instrument is stable, continuous injection of several doses of the standard solution until the two adjacent needles fenitrothion Danfeng area relative change After less than 1.5%, according to the solution, sample solution, sample solution, standard order of standard solution was measured. 4.3.5.4 Calculation The two needle sample solution and measured before and after the two doses of the standard sample solution fenitrothion Danfeng area were averaged. Sample CARTAP The mass fraction of 1 (%) according to equation (1). 1 = A2 (1) Where. A1 --- standard solution, fenitrothion mean Danfeng area; A2 --- sample solution, fenitrothion mean Danfeng area; --- CARTAP standard mass fraction, expressed as a percentage. 4.3.6 allowable difference CARTAP poor quality score of two parallel determination results shall not be greater than 1.2%, the arithmetic mean value as a measurement result. 4.4 Determination of Moisture According to GB/T 1600 in "azeotropic method". 4.5 Determination of insoluble matter 4.5.1 Reagents and Instruments Conical flask. 250mL; Glass sand core crucible. G3; Oven. 105 ℃ ± 2 ℃; Suction flask. 500mL. 4.5.2 Determination Weigh 10g sample (accurate to 0.01g), into a conical flask, 100mL water, shaking the sample has been dissolved immediately by Constant weight (accurate to 0.0002g) filter crucible, and then 60mL of water, washed three times Erlenmeyer flask filtration. The crucible was placed in an oven dried 2h, brought out in the dryer to cool and weigh (accurate to 0.0002g). 4.5.3 Calculation Sample water insolubles 2 (%) according to equation (2). (2) Where. 4.5.4 allowable difference Relative deviation parallel determination results shall be not more than 30% of the arithmetic mean as a measurement result. According to GB/T 1601 carried out. 4.7 product testing and acceptance Shall comply with GB/T 1604 regulations limit the use of numerical processing rounding value comparison method. 5 marking, labeling, packaging, storage and transportation Flag 5.1 CARTAP original drug, labeling, packaging shall comply with the provisions of GB 3796. 5.2 CARTAP original drug application of clean, dry polypropylene pail, net weight per barrel 25kg. 5.3 Other forms of packaging may be used according to user requirements or the order agreement, it should comply with the provisions of GB 3796. 5.4 CARTAP original drug package should be stored in well-ventilated, dry coffers. 5.5 storage, prevent moisture and sunlight, no food, seed, feed mix, avoid contact with skin, eyes, mouth and nose to prevent inhalation. 5.6 Security. CARTAP moderately toxic pesticides. Are swallowed or inhaled poisoning. The FDA should wear protective gloves, gas masks, wear dry Net protective clothing. After application, immediately wash with soap and water. In case of poisoning, please immediately sent to hospital for treatment. 5.7 Acceptance period. CARTAP original drug acceptance period of 1 month. From the date of delivery, the quality of the finished product acceptance within one month, the indicators It shall meet the standards. ......Tips & Frequently Asked Questions:Question 1: How long will the true-PDF of GB 22612-2008_English be delivered?Answer: Upon your order, we will start to translate GB 22612-2008_English as soon as possible, and keep you informed of the progress. The lead time is typically 1 ~ 3 working days. The lengthier the document the longer the lead time.Question 2: Can I share the purchased PDF of GB 22612-2008_English with my colleagues?Answer: Yes. 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